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In addition, while molecular docking provided mechanistic insights, in vitro validation of the proposed SIRT1-mediated pathways was not performed

Lieu CH, Lin Y, Kopetz S , Jacobs SA, Lucas PC, Sahin IH, Deming DA, Philip PA, Hong TS, Rojas-Khalil Y, Loree JM, Wolmark N, Yothers G, George TJ, Dasari A

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We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol